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Human Pain Genetics Database<\/p>\n
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The Human Pain Genes Database (HPGDB) is a comprehensive compilation of single nucleotide polymorphisms (SNPs) that have been reported to be associated with pain. Interpersonal variability in chronic pain etiology, acute pain sensitivity, and analgesic response has been suggestive of differences in genetic predisposition, a theory supported by the numerous genetic association studies published during the last twenty years. As common, generally low-effect markers of genetic variability, SNPs are instrumental in sampling this predisposition and in identification of risk-modifying genes. With an ever-growing number of studies, the HPGDB is a regularly-updated tabular summary of SNP-phenotype associations, populated via manually-curated literature review. It is intended to serve as a reference and to generate new hypotheses that may lead to a better understanding of underlying molecular mechanisms and consequently the development of personalized treatment.<\/p>\n
Results are presented in the following six-column format: genetic locus (or loci where applicable), SNP rsID, allele or haplotype reported in association analysis, direction of effect, associated phenotype, and citation. Additional information is displayed upon hovering over each field, and fields provide links to the corresponding reference database in NCBI and PubMed. The data is downloadable in a variety of formats.<\/p>\n