{"id":29,"date":"2020-09-08T07:17:02","date_gmt":"2020-09-08T07:17:02","guid":{"rendered":"http:\/\/www.c14898.sgvps.net\/~maramel8\/humanpaingenetics.org\/?page_id=29"},"modified":"2026-03-18T18:13:18","modified_gmt":"2026-03-18T18:13:18","slug":"landing","status":"publish","type":"page","link":"https:\/\/206-12-96-229.cloud.computecanada.ca\/","title":{"rendered":"Landing"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” admin_label=”Page Header” _builder_version=”4.16″ background_image=”https:\/\/206-12-96-229.cloud.computecanada.ca\/wp-content\/uploads\/2020\/09\/DSC_1875-scaled.jpg” global_colors_info=”{}”][et_pb_fullwidth_header title=”Welcome to the Human Pain Genetics Lab” text_orientation=”center” header_fullscreen=”on” header_scroll_down=”on” scroll_down_icon=”%%0%%” scroll_down_icon_size=”48px” button_one_url=”#” button_two_url=”#” admin_label=”Hero Section” _builder_version=”4.16″ title_font=”Montserrat|on|||” title_font_size=”60px” title_line_height=”1.4em” content_font_size=”22px” content_line_height=”1.8em” subhead_font=”||||” background_color=”rgba(255, 255, 255, 0)” use_background_color_gradient=”on” background_color_gradient_stops=”rgba(58,52,226,0.93) 0%|rgba(73,108,220,0.7) 100%” background_color_gradient_start=”rgba(58,52,226,0.93)” background_color_gradient_end=”rgba(73,108,220,0.7)” custom_button_one=”on” button_one_text_size=”16px” button_one_bg_color=”#6eba01″ button_one_border_width=”2px” button_one_border_color=”#6eba01″ button_one_border_radius=”0″ button_one_letter_spacing=”2″ button_one_font=”Montserrat|||on|” button_one_use_icon=”off” custom_button_two=”on” button_two_text_size=”16px” button_two_border_width=”2px” button_two_border_color=”#ffffff” button_two_border_radius=”0″ button_two_letter_spacing=”2″ button_two_font=”Montserrat|||on|” button_two_use_icon=”off” module_alignment=”left” custom_padding=”1px||0px|||” animation_style=”fade” button_one_text_color_hover=”#6eba01″ button_two_text_color_hover=”#6eba01″ button_one_border_color_hover=”#ffffff” button_two_border_color_hover=”#ffffff” button_one_border_radius_hover=”0″ button_two_border_radius_hover=”0″ button_one_letter_spacing_hover=”2″ button_two_letter_spacing_hover=”2″ button_one_bg_color_hover=”#ffffff” button_two_bg_color_hover=”#ffffff” global_colors_info=”{}” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_one_text_color__hover_enabled=”on” button_one_text_color__hover=”#6eba01″ button_two_text_color__hover_enabled=”on” button_two_text_color__hover=”#6eba01″ button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_one_border_color__hover_enabled=”on” button_one_border_color__hover=”#ffffff” button_two_border_color__hover_enabled=”on” button_two_border_color__hover=”#ffffff” button_one_border_radius__hover_enabled=”on” button_one_border_radius__hover=”0″ button_two_border_radius__hover_enabled=”on” button_two_border_radius__hover=”0″ button_one_letter_spacing__hover_enabled=”on” button_one_letter_spacing__hover=”2″ button_two_letter_spacing__hover_enabled=”on” button_two_letter_spacing__hover=”2″ button_one_bg_color__hover_enabled=”on” button_one_bg_color__hover=”#ffffff” button_two_bg_color__hover_enabled=”on” button_two_bg_color__hover=”#ffffff”]<\/p>\n

 <\/p>\n

 <\/p>\n

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Persistent pain is part of many common human clinical conditions, yet the current ability to diagnose and manage these conditions is inadequate. Pain perception is one of the most complicated measurable traits, as it is an aggregate of other measurable phenotypes associated with peripheral and central nervous system dynamics, stress responsiveness, and inflammatory state. It is generally accepted that complex traits, like pain perception, result from the interplay between environmental exposures and multiple genetic variants. However, little is known about the nature of these genetic variants. Due to the established role of environmental exposures, and the common view that pain perception is an unquantifiable and subjective experience, a genetic basis for pain perception has long been questioned. Thanks to recent and rapidly developing discoveries in the field of pain genetics, there is now evidence for genetic background playing a substantial role in pain perception and clinical pain phenotypes. These findings provide unique opportunities to identify genetic variants that contribute to pain phenotypes. The development of genome-wide approaches assures global and unbiased assessment of these genetic contributions.<\/p>\n

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The Human Pain Genetics lab investigates the psychological, molecular, cellular, and genetic pathways that mediate both acute and persistent pain states. Our primary goal is to identify the critical elements of human genetic variability contributing to pain sensitivity and pathophysiological pain states that will enable individualized treatments and therapies.<\/p>\n

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Current research projects at the Human Pain Genetics lab include: <\/b><\/p>\n

\u2022 <\/span>Identifying critical elements of human genetic variability contributing to pain sensitivity and pathophysiological pain states through genome-wide approaches.<\/p>\n

\u2022 <\/span>Identifying SNP-dependent regulation of gene function underlying variability in human molecular pain signaling.<\/p>\n

\u2022 <\/span>Identifying ways to enable individualized treatments and therapies for human pain<\/p>\n

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Team<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_padding=”23px|0px|27px|0px||” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_team_member name=”Xiang Ao” image_url=”https:\/\/206-12-96-229.cloud.computecanada.ca\/wp-content\/uploads\/2024\/04\/20231121_AcademicHeadshot_220x220.jpg” admin_label=”Member 01″ _builder_version=”4.24.2″ header_font=”||||||||” header_text_color=”#013569″ header_font_size=”18px” header_line_height=”2em” body_text_align=”center” body_text_color=”#666666″ body_font_size=”16px” background_size=”initial” background_position=”top_left” background_repeat=”repeat” text_orientation=”center” custom_padding=”|||” animation_style=”fold” animation_direction=”bottom” 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global_colors_info=”{}”][\/et_pb_team_member][et_pb_team_member name=”Calvin Surbey” image_url=”https:\/\/206-12-96-229.cloud.computecanada.ca\/wp-content\/uploads\/2020\/11\/IMAGE-VECTOR.png” admin_label=”Member 01″ _builder_version=”4.27.4″ header_font=”||||||||” header_text_color=”#013569″ header_font_size=”18px” header_line_height=”2em” body_text_color=”#666666″ body_font_size=”16px” background_size=”initial” background_position=”top_left” background_repeat=”repeat” text_orientation=”center” custom_padding=”|||” animation_style=”fold” animation_direction=”bottom” animation_delay=”100ms” animation_intensity_fold=”20%” locked=”off” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Mohamad Karaky” image_url=”https:\/\/206-12-96-229.cloud.computecanada.ca\/wp-content\/uploads\/2024\/04\/Mohamad_01_220.png” admin_label=”Member 01″ 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Past Members<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.24.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.24.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”17px” custom_margin=”||20px||false|false” global_colors_info=”{}”]<\/p>\n

Rodrigo Benavides
\nStefano Cattaneo
\nAnne-Julie Chabot-Dore\u0301
\nIvan Chumakov
\nKelly Cool
\nKhady Diagne
\nMaria Di Nezza
\nPavel Gris
\nHao Huang
\nArturo I. Machuca Parra
\nSarah Jane Martinez
\nSamar Khoury
\nRichard Klares
\nRyan Lichtenwalter
\nCarol Meloto
\nMeijuan Niu
\nLorenna Oliveira Fernandes de Araujo
\nAnahita Oveisi
\nMarjo Piltonen
\nLisanne Plein
\nAlexander Samoshkin
\nJulia Segal
\nXia (Shawn) Wen
\nYerkebulan Talzhanov
\nAdam Trefonides
\nNicol Tugarinov
\nSonali Uttam
\nVivek Verma
\nMaria Verner
\nAbdul Wahab
\nNatalie Zacchia
\nMaha Zidan
\nKaterina Zorina<\/p>\n

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   Persistent pain is part of many common human clinical conditions, yet the current ability to diagnose and manage these conditions is inadequate. Pain perception is one of the most complicated measurable traits, as it is an aggregate of other measurable phenotypes associated with peripheral and central nervous system dynamics, stress responsiveness, and inflammatory state. […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-29","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/206-12-96-229.cloud.computecanada.ca\/index.php?rest_route=\/wp\/v2\/pages\/29","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/206-12-96-229.cloud.computecanada.ca\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/206-12-96-229.cloud.computecanada.ca\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/206-12-96-229.cloud.computecanada.ca\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/206-12-96-229.cloud.computecanada.ca\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29"}],"version-history":[{"count":54,"href":"https:\/\/206-12-96-229.cloud.computecanada.ca\/index.php?rest_route=\/wp\/v2\/pages\/29\/revisions"}],"predecessor-version":[{"id":1922,"href":"https:\/\/206-12-96-229.cloud.computecanada.ca\/index.php?rest_route=\/wp\/v2\/pages\/29\/revisions\/1922"}],"wp:attachment":[{"href":"https:\/\/206-12-96-229.cloud.computecanada.ca\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}